This document, created by Pennsylvania State University and hosted by the Nanotechnology Applications and Career Knowledge Network, serves as a guide for a laboratory activity where students "create a basic SPC graph for maintaining gold nanoparticle manufacturing controls" and "how to read and interpret control charts and how to determine when a manufacturing process may need to be investigated for errors." The lab guide includes objectives, an introduction to Statistical Process Control (SPC) and Transmission Electron Microscopy (TEM), an overview of the ImageJ software to be used in the lab, step-by-step directions to the lab activity itself, and post-lab questions to test student comprehension. In order to access and download this material, users must complete a free registration.