This lesson, presented by the National Nanotechnology Infrastructure Network, consists of two activities, 'Fly Poison' and 'Water Maze,' to introduce students to self-assembly in nanotechnology. 'Fly Poison' models how "researchers build very small devices by the self-assembly of molecules" for real-world applications, while 'Water Maze' gives them an opportunity to practice this new knowledge. The included 'Teacher's Preparatory Guide' details needed materials, and step-by-step instructions to leading the activities. A student worksheet includes activity introduction and instructions, as well as questions to assess comprehension. A separate teacher's guide and 'Challenge Cards' are included for the follow-up 'Water Maze' activity.